Low- and high-flux hemodialysis membranes in maintenance hemodialysis：permeability, adsorbability and biocompatibility
10.3969/j.issn.2095-4344.2015.38.022
- VernacularTitle:高低通量血液透析膜在维持性血液透析过程中的通透性、吸附性和生物相容性
- Author:
Zongyang LIU
;
Yi XIE
;
Yan CHEN
;
Yan JIANG
;
Fuxi GU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(38):6190-6194
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Dialysis membrane is the most important part of a dialyzer, which directly affects the therapeutic efficacy of hemodialysis.
OBJECTIVE:To study the permeability, adsorbability and biocompatibility of high- and low-flux hemodialysis membrane in maintenance hemodialysis process.
METHODS:Forty-six hemodialysis patients due to chronic renal failure were selected, including 24 males and 22 females, aged 26-78 years. These patients were randomized into two groups: FX8 and FX60 groups. Dialog+ dialyzer and bicarbonate dialysate (Braun, Germany) were used in the two groups, and polysulfone membranes FX8 and FX60 were respectively used in the two group. Al the patients received hemodialysis three times per week, 4 hours once. After 4 months of dialysis, blood levels of toxins and inflammatory cytokines were detected in the two groups.
RESULTS AND CONCLUSION:After dialysis, there were no differences in the blood urea nitrogen, serum creatinine, blood phosphorus levels between the two groups. The clearance rates of β2-microglobulin and parathyrin were significantly higher in the FX60 group than the FX8 group (P < 0.05); the plasma levels of albumin and hemoglobin were significantly higher in the FX60 group than the FX8 group (P < 0.05); but the serum levels of interleukin-8 and tumor necrosis factor-a were lower in the FX60 group than the FX8 group (P < 0.05). These findings indicate that high-flux polysulfone membrane FX60 is superior to low-flux polysulfone membrane FX8 in the clearance of macromolecule toxins and biocompatibility.
