Role of Nrf2/Keap1/ARE signaling pathway in respiratory diseases
10.3969/j.issn.1001-1978.2015.11.003
- VernacularTitle:Nrf2/Keap1/ARE信号通路与难治性呼吸系统疾病研究进展
- Author:
Ping ZHAO
;
Jian GAO
- Publication Type:Journal Article
- Keywords:
refractory respiratory diseases;
oxidative stress;
Nrf2/Keap1/ARE signaling pathway;
pulmonary fibrosis;
lung cancer;
chronic obstructive pulmonary disease;
acute lung injury;
bronchial asthma
- From:
Chinese Pharmacological Bulletin
2015;(11):1488-1492
- CountryChina
- Language:Chinese
-
Abstract:
Nrf2/Keap1/ARE is an important signaling pathway in maintaining the balance between peroxide and antioxidants. Once oxidative stress happened, Nrf2/Keap1/ARE would be ac-tivated to regulate the expression of downstream antioxidant pro-teins that could reduce the injury from oxidative stress and the level of oxidative stress. Recent researches show that Nrf2/Keap1/ARE signaling pathway is closely related to refractory re-spiratory diseases such as pulmonary fibrosis (PF), lung canc-er, chronic obstructive pulmonary disease (COPD), suggesting that Nrf2/Keap1/ARE signaling pathway may be a potential ther-apeutic target. This review focuses on the role of Nrf2/Keap1/ARE signaling pathway in refractory respiratory diseases in order to further understand the related mechanism and provide evidence for the diagnosis and treatment of refractory respiratory diseases.
