Diagnostic value of matrix gamma carboxy glutamic acid protein for coronary heart disease
10.3969/j.issn.1673-4130.2015.21.005
- VernacularTitle:基质γ-羧基谷氨酸蛋白对冠心病的诊断价值研究
- Author:
Jian XU
;
Qingna ZENG
;
Shan HUANG
;
Chunyang ZHANG
;
Jie CHEN
;
Qinying FENG
;
He TIAN
;
Zhiqin LIU
;
Rongpin WANG
- Publication Type:Journal Article
- Keywords:
matrix gamma carboxy glutamic acid protein;
coronary atherosclerotic heart disease;
coronary artery calcifica-tion;
diagnosis value
- From:
International Journal of Laboratory Medicine
2015;(21):3088-3089
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of matrix gamma carboxy glutamic acid protein(MGP) for coronary heart disease(CHD) .Methods Enzyme linked immunosorbent assay was performed for the detection of serum MGP level in health‐y subjects and CHD patients with different coronary artery calcium score(CACS) .Receiver operating characteristic(ROC) curve was used to analyze the diagnostic value of MGP for CHD .Results Between CHD patients and healthy subjects ,and CHD patients with different CACS ,the difference of serum MGP level was significant ,and serum MGP level was positively correlated with CACS (P<0 .05) .ROC curve of showed that the area under ROC curve was 0 .667 ,the diagnostic threshold was 70 .69 pg/mL ,the diag‐nostic sensitivity was 58 .80% ,the specificity was 83 .70% and the Youden index was 0 .425 .Conclusion CHD patients might be with abnormal serum MGP level ,which could be positively correlated with CACS .MGP might be with significant value for the diag‐nosis of CHD ,could be useful for the clinical prevention and early diagnosis of CHD .
