Correlation between endothelial microparticles and interleukin-6 and C-reactive protein in patients with coronary heart disease
10.3969/j.issn.1673-4130.2015.21.014
- VernacularTitle:冠心病患者外周血内皮微粒变化及其与炎症因子的相关性研究
- Author:
Lihui ZHENG
;
Fei GUO
;
Xiao HAN
;
Lijuan HUANG
- Publication Type:Journal Article
- Keywords:
endothelial microparticles;
coronary heart disease;
interleukin-6;
C-reactive protein
- From:
International Journal of Laboratory Medicine
2015;(21):3112-3114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate alterations of endothelial microparticles(EMPs) levels in patients with coronary heart dis‐ease(CHD) ,and to evaluate the relationship between EMPs and interleukin‐6(IL‐6) and C‐reactive protein(CRP) .Methods A to‐tal of 38 patients with CHD were divided into myocardial infarction(MI) group(13 cases) and unstable angina(UA) group(13 ca‐ses) and stable angina(SA) group(12 cases) ,and 12 healthy subjects were enrolled as control group .Levels of EMPs were meas‐ured by using flow cytometry technique .Concentration of IL‐6 and CRP were determined by using enzyme linked immunosorbent assay and special protein analysis respectively .Results Compared with SA group and control group ,levels of EMPs were signifi‐cantly increased in MI group and UA group(P<0 .05) .Levels of EMPs in patients with CHD were significantly correlated with IL‐6 and CRP ,with correlation coefficient of 0 .79 and 0 .50 respectively(P<0 .05) .Conclusion EMPs could contribute to monitoring and evaluating the degree of endothelial cells injury in patients with CHD as a laboratory indicator .EMPs might enhance the vascu‐lar inflammation in patients with CHD ,and further accelerate the development of CHD .
