MicroRNAs and atherosclerosis
10.3760/cma.j.issn.1673-4165.2015.08.013
- VernacularTitle:微小RNA与动脉粥样硬化
- Author:
Dingchao HUA
;
Xiaoguang YAN
;
Geng GUO
;
Chenyang LU
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Atherosclerosis;
Lipoproteins,LDL;
Inflammation;
Gene Expression Regulation
- From:
International Journal of Cerebrovascular Diseases
2015;(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is the most important cause of ischemic stroke. microRNAs can play an important role in the lipid metabolism, vascular inflammatory response, angiogenesis, as wel as smooth muscle cel proliferation and phenotypic conversion, etc. by regulating the functions of vascular endothelial cel s, vascular smooth muscle cel s, and mononuclear macrophages. It is closely associated with the occurrence and development of atherosclerosis. This article mainly reviews the regulatory effect of microRNAs on lipid metabolism and vascular inflammatory response in pathogenesis of atherosclerosis.
