Association of collagen type I alpha1 Sp1 polymorphism with bone mineral density and fracture：a Meta-analysis of case-control studies
10.3969/j.issn.2095-4344.2015.33.027
- VernacularTitle:Ⅰ型胶原α1 Sp1多态性与骨密度和骨折关联性的Meta分析
- Author:
Qiang ZONG
;
Lijun LI
;
Zhuyan JIANG
;
Yubo SHI
;
Dongkui NI
- Publication Type:Journal Article
- Keywords:
Fractures,Bone;
Collagen Type I;
Bone Density;
Meta-Analysis
- From:
Chinese Journal of Tissue Engineering Research
2015;(33):5395-5401
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Currently, there are large numbers of studies related to the association between colagen type I alpha1 (COL1A1) Sp1 polymorphism and bone mineral density and fracture risk, but the results are inconsistent. OBJECTIVE:To evaluate the impact of the COL1A1 Sp1 polymorphism on bone mineral density and fracture by using the Meta-analysis. METHODS:We comprehensively searched the eligible studies for the present meta-analysis through MEDLINE, PubMed, EMBASE databases. Pooled odds ratios and 95% confidence intervals of Sp1 polymorphisms for bone mineral density and fracture risk were obtained, with attention to study quality and publication bias. RESULTS AND CONCLUSION:A total of 32 studies met the inclusion criteria, among which, 22 studies evaluated the Sp1 polymorphism and fracture risk. Significant associations were found in five genetic models. In the stratified analysis by region, the same results were found in the Europeans but not Americans and Asians. Thirteen studies evaluated the Sp1 polymorphism and low bone mineral density risk. A similar result was obtained. However, the analysis of bone mineral density data showed an increased relation between Sp1 polymorphism and low bone mineral density in Europeans and Americans but not in Asians. Overal, the current meta-analysis concludes that the COL1A1 Sp1 polymorphism is associated with low bone mineral density and fracture risk, especialy in Europeans. However, susceptibility to them varies markedly among populations from different regions.
