Expression of macrophage migration inhibitory factor in keloid
10.3969/j.issn.2095-4344.2015.33.018
- VernacularTitle:巨噬细胞移动抑制因子在瘢痕疙瘩中的表达
- Author:
Guifeng LI
;
Chunmei WANG
;
Xian ZHOU
;
Lun YAN
;
Xiaofei XIANG
;
Wei XU
;
Sifen YANG
;
Jiabiao REN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Immunity;
Inflammation;
Fibrosis
- From:
Chinese Journal of Tissue Engineering Research
2015;(33):5338-5343
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Macrophage migration inhibitory factor is involved in the process of a variety of diseases, and plays a very important role in the tumor, autoimmune diseases, inflammation, angiogenesis, fibrotic diseases and so on. These biological characteristics are similar to keloids. OBJECTIVE: To compare the distribution and number of macrophage migration inhibitory factor in normal skin, hypertrophic scar and keloid. METHODS: We colected 40 clinical pathological scar specimens after surgery, including 20 hypertrophic scars and 20 keloids. Another 10 samples of the normal skin were used as control group. Hematoxylin-eosin staining and immunohistochemistry staining were performed to test the expression of macrophage migration inhibitory factor in pathological scars and normal skin. RESULTS AND CONCLUSION:Macrophage migration inhibitory factor was positively expressed in the normal skin, hypertrophic scar and keloid, and the expression of macrophage migration inhibitory factor in keloid was significantly higher than that in hypertrophic scar and normal skin (P < 0.01). It means that the abnormal infiltration of macrophage migration inhibitory factor may be associated with the formation of keloid.
