Two Cases of Autoimmune Insulin Syndrome with Hypoglycemia.
- Author:
See Hyung PARK
1
;
Shin Won LEE
;
Gui Hwa JEONG
;
Chang Hoon CHOI
;
Soon Hee LEE
;
Jeung Hoon HAN
;
Jeong Guk KIM
;
Seong Woo HA
;
Bo Wan KIM
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Insulin autoantibody;
Hyperinsulinemia;
Hypoglycemia
- MeSH:
C-Peptide;
Fasting;
Glucose Tolerance Test;
Hyperinsulinism;
Hypoglycemia*;
Immunization;
Insulin*;
Insulinoma;
Pancreas
- From:Journal of Korean Society of Endocrinology
2001;16(4-5):508-513
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Autoimmune insulin syndrome is characterized by insulin autoantibody, hyperinsulinemia, and fasting hypoglycemia without previous insulin immunization. This syndrome shows discordant levels between immunoreactive insulin and C-peptide. Negative results of an anatomic study of the pancreas and an inability to reproduce hypoglycemia during a prolonged fast may be helpful in excluding insulinoma. Symptomatic hypoglycemia usually develops during an oral glucose tolerance test. This syndrome is a self-limited disorder. Recently, we experienced one case that developed symptomatic hypoglycemia during both the fasting & oral glucose tolerance test, and another that developed symptomatic hypoglycemia during the oral glucose tolerance test but not the fasting test. Hereby, we present these cases with a review of the literature.
