Synthesis of N-acyl chitosan derivatives and investigation of chitosan-modified docetaxel liposomes in vitro

VernacularTitle:N-酰化壳聚糖的合成及其修饰多西他赛脂质体的体外性质研究
Author: Liang GE ; Hai QIAN ; Hao GAO ; Yaojian CHENG ; Jiabi ZHU
Publication Type:Journal Article
Keywords: N-acyl chitosan; doxetaxel; liposome; release
From: Journal of China Pharmaceutical University 2009;40(6):519-523
CountryChina
Language:Chinese
Abstract: Aim: Synthesized N-acylated chitosan(NAC) was used to anchor on the surface of plain docetaxel li-posomes( PDL) in order to to sustain drug release. Methods; NAC of low substitution degrees were prepared using hexanoic(C_6), lauric( C_(12)), and palmitic( C_(16)) anhydrides. W-palmitoyl chitosan was chosen to anchor the do-cetaxel liposomes. In vitro release profiles of conventional liposmes and the anchored liposomes was compared. Results: Hexanoic(C_6), lauric( C_(12)), and palmitic( C_(16)) -branched chitosans were synthesized. It was found that N-acylated chitosan-anchored DXL liposomes (NDL) increase stabilities of docetaxel liposomes. 70% of docetaxel was released from PDL in 24 hours but 39% from NDL Conclusion: Liposomes anchored by the low substituted N-acylated chitosan could decrease the drug release.