Synthesis and anti-inflammatory activity of α-aryl-3,5-dimethoxyphenylpro-penamides
10.3321/j.issn:1000-5048.2009.04.003
- VernacularTitle:α-芳基-3,5-二甲氧基苯丙烯酰胺的合成及抗炎活性
- Author:
Guizhen AO
;
Liling ZHENG
;
Guanglin XU
;
Jing LI
- Publication Type:Journal Article
- Keywords:
α-aryl-3;
5-dimethoxyphenylpropenamides;
synthesis;
anti-inflammatory activity
- From:
Journal of China Pharmaceutical University
2009;40(4):302-305
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To search for new compounds with stronger anti-inflammatory activities and less gastrointestinal side effects. Methods: 2-(2, 4-Dichlorophenyl) -3-(3, 5-dimethoxyphenyl) - propenoic acid(Ⅰ) was converted to amides(Ⅱ). Their anti-inflammatory activities against xylene-induced mice ear swelling were evaluated. Results: Twelve target compounds (Ⅱ_(1-12)) were synthesized, and their structures were confirmed by IR,~1H NMR and HR-MS.Ⅱ_3 exhibited significant anti-inflammatory activity compared with CMC-Na ( P < 0. 01) and aspirin ( P < 0. 05). Conclusion: Compound Ⅱ_3 deserves further investigation.
