Role of intestinal cytochrome P450s in drug metabolism
- VernacularTitle:小肠CYP450酶在药物代谢中的作用
- Author:
Shanshan XIE
;
Xinyue JING
;
Xiaodong LIU
- Publication Type:Journal Article
- Keywords:
cytochrome P450;
intestinal first-pass metabolism;
drug interaction;
drug metabolism
- From:
Journal of China Pharmaceutical University
2010;41(2):186-192
- CountryChina
- Language:Chinese
-
Abstract:
The uptake of oral administered drugs primarily occurs in the small intestine,which also has the capability to metabolize drugs.Both phase Ⅰ and phase Ⅱ metabolic enzymes were expressed in the intestinal mucosa,and cytochromes P450(CYP450s) are the principle enzymes attributed to the biotransformation of drugs.CYP3A and CYP2C are the most abundant subfamilies,accounting for approximately 80% and 16% of total CYP450s in the intestine.Compared to the liver,the expression and activity of CYP450 enzymes in the intestine was susceptible to inducers or inhibitors,leading to drug-drug interaction.This article reviews the expression of CYP enzymes in small intestine and the role of the gut wall in CYP-mediated xenobiotic metabolism.Possible drug-drug interactions due to induction or inhibition of CYP enzymes in the small intestine are also addressed.
