Therapeutic effects of ZK_(14), a novel nitric oxide donating biphenyldicarboxylate derivative, on hepatic fibrosis in rats

VernacularTitle:一氧化氮供体型联苯双酯衍生物ZK_(14)对大鼠肝纤维化的治疗作用
Author: Li DAI ; Lu ZHANG ; Hui JI ; Xiangwen KONG
Publication Type:Journal Article
Keywords: nitric oxide donor; hepatic fibrosis; CCl_4; biphenyldicarboxylate
From: Journal of China Pharmaceutical University 2009;40(3):254-257
CountryChina
Language:Chinese
Abstract: Aim: To study the therapeutic effects of ZK_(14), a novel nitric oxide donor, on hepatic fibrosis in rats. Methods: Rats were injected intraperitoneally with CCl_4 and induced to hepatic fibrosis, followed by intra-gasrtic administration with high dose of 20 mg/kg and low dose of 10 mg/kg of ZK_(14) for 4 weeks. The effects were evaluated in the content of nitric oxide of serum and nitric oxide synthases of liver, in serum levels of the hepatic functions indices and hepatic fibrotic index and in liver histopathology. Results: The biochemical indices and pathology grade were effectively improved in the group of ZK_(14) 20 mg/kg, and liver function was also effectively protected in this group. Conclusion: ZK_(14), a novel nitric oxide donating biphenyldicarboxylate derivative, showed preferable therapeutic effects on hepatic fibrosis of rats induced with CC14, and it may be of potential value in the treatment of hepatic fibrosis.