Synthesis and in vitro antitumor activities of novel soladulcidine derivatives
- VernacularTitle:新型蜀羊泉碱衍生物的合成及体外抗肿瘤活性
- Author:
Xiaoming ZHA
;
Feiran ZHANG
;
Jiaqi SHAN
;
Yanke CHEN
;
Yihua ZHANG
;
Jun LIU
;
Hongbin SUN
- Publication Type:Journal Article
- Keywords:
soladulcidine derivatives;
synthesis;
antitumor activity
- From:
Journal of China Pharmaceutical University
2010;41(6):493-498
- CountryChina
- Language:Chinese
-
Abstract:
Soladulcidine is a steroidal alkaloid abundant in Solanum dulcamara L. with antitumor and other biological activities. In this study, ten soladulcidine derivatives were synthesized through esterification at C-3-hydroxy group, modification at NH group of F ring of esterification of E ring-opening products. The in vitro antiproliferative activity of these synthesized derivatives against prostate cancer (PC-3) cell line was assessed. Within this series of compounds, compound 19 exhibited the most potent inhibitory effect against the proliferation of PC-3 cell line (IC50=4.80±.9μmol/L).
