Synthesis and antitumor activity of ent-kaurene diterpenoids
- VernacularTitle:ent-贝壳杉烯类化合物的合成及其抗肿瘤活性
- Author:
Dayong ZHANG
;
Yong TANG
;
Ke WANG
;
Xiaoming WU
;
Weiyi HUA
- Publication Type:Journal Article
- Keywords:
ent-kaurene;
stevioside;
exo-methylene eyelopentanone;
antitumor activity;
synthesis
- From:
Journal of China Pharmaceutical University
2010;41(1):20-25
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To synthesize the ent-kaurene diterpenoid and its derivatives from natural available stevioside.Methods: The crucial pharmacophore of exo-methylene ketone was designed and the carboxyl group at C-4 was modified.The cytotoxic inhibition activities in vitro of target compounds were evaluated against human cancer cells BEL-7402,HO-8910,MCF-7 and HL-60 by a MTT method.Results and Conclusion: The struc-tures of new target compounds were identified by ~1H NMR,FT-IR and EI-MS.The preliminary experimental re-sults showed that some derivatives of ent-kaurene diterpenoid possessed fair inhibitory activity against tumor cell lines compared with that of their parent steviol.
