Transcription factors as new targets for cancer therapy
- VernacularTitle:转录因子——新型抗肿瘤药物作用靶点
- Author:
Nan LIU
;
Yijun CHEN
- Publication Type:Journal Article
- Keywords:
transcription factor;
anti-tumor;
NF-κB;
signal transducer and activator of transcription;
nuclear factor of activated T-cells
- From:
Journal of China Pharmaceutical University
2010;41(2):97-103
- CountryChina
- Language:Chinese
-
Abstract:
Mechanism studies in the gene regulation in the eukaryotic cells is one of the momentous areas in molecular biology.Regulation at transcription level is a complex progress with multiple steps with the presence of the gene functions.There exist ubiquitous occurrence of transcription factors in mammalian tissues and biodiversity in the factors.These transcription factors are found to relate closely to various carcinogeneses,including cell proliferation,apoptosis,invasion and angiogenesis.Understanding of transcription factors and their action mechanisms,through the activation and inhibition of transcription factors,would potentially lead to the discovery of new entities in the targeting treatment and prevention of the cancer diseases.
