Toxicity of glufosfamide in Beagle dogs following intravenous injection

VernacularTitle:葡膦酰胺静脉给药对比格犬的毒性作用
Author: Yanwei DING ; Zuokui LI ; Hua ZHAO ; Jianxin ZHANG ; Baoqiu LI
Publication Type:Journal Article
Keywords: glufosfamide; Beagle dog; toxicity
From: Journal of China Pharmaceutical University 2009;40(6):535-538
CountryChina
Language:Chinese
Abstract: Aim: To evaluate the safety of glufosfamide in Beagle dogs. Methods: The safety of glufosfamide in Beagle dogs following single iv and multiple iv administration for 3 months was observed. Results: The minimum lethal dose of glufosfamide was 100 mg/kg. The maximum non-lethal dose of glufosfamide was 50 mg/kg. The approximate lethal dose of glufosfamide was 75-100 mg/kg. No serious adverse reactions was observed in Beagle dogs following multiple iv administration once a week for 3 months at the dose of 20 mg/kg, 40 mg/kg, and 60 mg/kg. However, organ injury was observed extensively in the high dose-group and mediumt-dose group. The low-dose group showed a light change in individual organs. Conclusion: Under the experimental conditions, 40 mg/kg and 60 mg/kg iv administration once a week for 3 months can lead to extensive organ injury in Beagle dogs, so the dose shouldn't be higher than 20 mg/kg.