Non-traditional antiarrhythmic medicines for atrial fibrillation
- VernacularTitle:非传统抗心律失常药物对房颤的治疗
- Author:
Lei CHEN
;
Jin YANG
- Publication Type:Journal Article
- Keywords:
atrial fibrillation;
inflammation;
oxidative stress;
RAAS;
gap junction
- From:
Journal of China Pharmaceutical University
2010;41(1):86-90
- CountryChina
- Language:Chinese
-
Abstract:
Atrial fibrillation is the most common arrhythmia in clinical practice.However,the therapeutic effects of traditional antiarrhythmic medicines are far from satisfactory,because of the high rate of arrhythmia recurrence and the potential proarrhythmia effect.Recently,with the further investigation of the mechanisms that initiate and perpetuate atrial fibrillation,and the support of extensive data from clinical trials and animal experiments,thera-peutics based on anti-inflammation,antioxidation,regulation on renin-angiotensin-aldosterone system(RAAS)and gap junction may be new therapeutic targets for the treatment of arrhythmia.In this paper,the potential molecular mechanisms involved in these processes and several clinical trials about some non-traditional antiarrhythmic medi-cines were reviewed,in order to propose a new idea about the development of antiarrhythmic medicines.
