Progress in the research of chemical structural modification of ursolic acid and structure-activity relationship
10.3321/j.issn:1000-5048.2009.06.022
- VernacularTitle:熊果酸化学结构修饰与构效关系的研究进展
- Author:
Kaibo ZHENG
;
Chengbin SUN
;
Haili MAO
;
Zaibo YANG
- Publication Type:Journal Article
- Keywords:
ursolic acid;
chemical structural modification;
structure-activity relationship
- From:
Journal of China Pharmaceutical University
2009;40(6):580-584
- CountryChina
- Language:Chinese
-
Abstract:
Ursolic acid, a pentacyclic triterpene compound, naturally occurs in a large variety of plants, has at-tracted considerable interest owing to its significant biological activities. In recent years, more and more scientists have been working on the structural modification at the C-3 position , C_(12)-C_(13) double bond or C-28 position of ur-solic acid in order to improve their biological activities. Herein a brief introduction of the recent progresses on the chemical structural modification and the structure-activity relationship of ursolic acid and its derivatives are re-viewed.
