Improved synthesis of 2,5 -anhydro-3,4,6-tri- O-benzyl-D-glucitol
10.3321/j.issn:1000-5048.2009.03.003
- VernacularTitle:2,5-脱水-3,4,6-O-三苄基-D-葡萄糖醇的改进合成方法
- Author:
Ben NIU
;
Jiaqi SHAN
;
Xiaoming WU
;
Hongbin SUN
- Publication Type:Journal Article
- Keywords:
2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol;
synthesis;
antitumor drug
- From:
Journal of China Pharmaceutical University
2009;40(3):205-208
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To improve the synthesis for 2, 5-anhydro-3,4, 6-tri-O-benzyl-D-glucitol. Methods: Dehydration of D-mannitol, followed by a reaction sequence of selective protection, benzylation, deprotection, tritylation, benzy-lation and removal of the trityl group, afforded the title compound. Results: Based on the improvement of the reported synthetic route, 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol was synthesized in seven steps from D-mannitol with a total yield of 8. 3% . Conclusion: This new method features mild reaction conditions and facile work-up.
