Isolation and characterization of a marine actinomyces LYG-1 with antitumor activity
- VernacularTitle:抗肿瘤海洋放线菌LYG-1的筛选及分类鉴定
- Author:
Yingying XING
;
Yuanyuan LU
;
Yihua MA
;
Weiwei BAO
;
Tao XI
- Publication Type:Journal Article
- Keywords:
marine actinomyces;
isolation and characterization;
Streptomyces roseosporus;
antitumor activity
- From:
Journal of China Pharmaceutical University
2012;43(4):366-370
- CountryChina
- Language:Chinese
-
Abstract:
Marine actinomyces LYG-1 was isolated from marine mud flats in Lianyungang,China.Strain LYG-1 was identified using the methods of morphology,physiological and ehemotaxonomic characterization and 16S rRNA gene sequence analysis.The results showed that strain LYG-1 was a marine variable species of Streptomyces roseosporus.The fermentation broth of strain LYG-1 exhibited conspicuous antitumor activity against HepG2,MCF-7,HCT116 and MDA-MB-231 cell lines,and the IC50 values were defined by MTT method respectively.
