Preparation and characterization of diclofenac sodium layered double hydroxide nanohybrids
10.3321/j.issn:1000-5048.2009.04.007
- VernacularTitle:双氯芬酸钠层状双金属氢氧化物纳米复合物的制备及性质研究
- Author:
Yanjun WANG
;
Feng CAO
;
Qineng PING
- Publication Type:Journal Article
- Keywords:
layered double hydroxides;
diclofenac sodium;
drug-inorganic nanohybrids;
characterization;
release in vitro;
anti-inflammatory activity
- From:
Journal of China Pharmaceutical University
2009;40(4):321-326
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To prepare diclofenac sodium-layered double hydroxide nanohybrids(DS-LDH) and investigate its properties. Methods: The diclofenac sodium anions were hybridized with LDH by co-precipitation. The synthetic nanohybrids were characterized by various methods, such as laser particle sizer, XRD, IR, and TEM. Paddle method according to the Chinese Pharmacopoeia was used to determine the dissolution. The anti-inflammation of nanohybrids and diclofenac sodium were compared by the effect on auricular tumescence induced by xylene in mice. Results: The acidic negative ion of layered double hydroxides were replaced by the diclofenac anion to form DS-LDH. Release studies showed that the nanohybrids could serve as controlled release systems for DS. Zn-Al-NO3-LDH was proved to have character of neutral pH which is more suitable for orphthalmic preparation. The DS-LDH nanohybrids could keep the effect of anti-inflammation. Conclusion: Layered double hydroxide nanohybrids can be used as sustained-release carrier of anionic drugs. A novel type of drug-inorganic nanohybrids was prepared successfully which has a potential value of clinical application.
