Application of pharmacometrics in drug development and therapeutic drug monitoring
- VernacularTitle:定量药理学在新药研发及临床治疗药物监测方面的应用
- Author:
Dewei SHANG
;
Xipei WANG
;
Chenhui DENG
;
Shanshan BI
;
Zheng GUAN
;
Tianyan ZHOU
;
Wei LU
- Publication Type:Journal Article
- Keywords:
pharmacometrics;
new drug research and development;
therapeutic drug monitoring;
individualized therapy
- From:
Journal of China Pharmaceutical University
2010;41(1):91-96
- CountryChina
- Language:Chinese
-
Abstract:
Pharmacometrics,developed from the conventional pharmacokinetics,is the science of applying mathe-matical and statistical methods to characterize,understand,and predict a drug's pharmacokinetic,phannacodyna-mic,and biomarker-outcome behaviors.Pharmacometrics has been widely valued for its utility of modeling and simulation in drug research and development,therapeutic drug monitoring and individualized therapy.This paper reviewed the advances of pharmacometrics employed in new drug research and development and therapeutic drug monitoring both at home and abroad.
