The features of patients with cyclic citrullinated peptide antibodies in primary Sj(o)gren's syndrome
10.3760/cma.j.issn.1008-1372.2015.08.025
- VernacularTitle:原发性干燥综合征中抗CCP抗体阳性患者的临床及实验室特点分析
- Author:
Jing GUO
;
Yongfu WANG
;
Xiuli SUN
- Publication Type:Journal Article
- Keywords:
Sj(o)gren's syndrome/ME/DI;
Peptides,cyclic/ME;
Autoantibodies/ME
- From:
Journal of Chinese Physician
2015;17(8):1212-1214
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the features of patients with cyclic citrullinated peptide (CCP) antibodies in primary Sj(o)gren's syndrome (pSS) with the retrospective method.Methods Seventy eight pSS patients were studied.Enzyme-linked immunosorbent assay (ELISA) indirect immunofluorescence was used to measure anti-CCP antibodies.The patients with and without anti-CCP antibodies were correspondingly classified as autoantibody-positive and negative pSS groups.Clinical and laboratory features were compared between autoantibody-negative and positive group.Results (1) Seven (9.0％) of pSS patients had positive anti-CCP antibody.No significant difference was found in sex,ages,and disease course between autoantibody-nagative and positive pSS patients.(2) The anti-CCP-positive pSS was associated with the rates of decayed tooth,fatigue,dry mouth,dry eyes,and tender of joint (P ＜ 0.05).Whereas,the antiCCP-negative pSS was not significantly related to fever and mumps (P ＞ 0.05).(3)From serologic characteristics aspects,the anti-CCP-positive patients showed higher level of tender of joint than the anti-CCP-negative patients.No significant difference was found in white blood cell (WBC),hemoglobin (HGB),platelet (PLT),erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),immunoglobulin A (IgA),IgG,IgM,and rheumatoid factor (RF) between two groups (P ＞ 0.05).Conclusions The anti-CCP-positive patients were 9％ ofpSS patients,and were more likely to occur tender of joint with higher level of tender of joint.
