The research progress of Lynch syndrome-associated endometrial cancers

VernacularTitle:Lynch综合征相关性子宫内膜癌的研究进展
Author: Fei TENG ; Xuegong MA ; Fengxia XUE
Publication Type:Journal Article
Keywords: Colorectal neoplasms,hereditary nonpolyposis/DI/CO; Endometrial neoplasms/CO/PA/DI/PC; Review
From: Journal of Chinese Physician 2015;17(8):1131-1134
CountryChina
Language:Chinese
Abstract: Lynch syndrome.(LS) is an autosomal dominant condition caused by a mutation in the mismatch repair genes (MMR).Endometrial cancer (EC) is the most common extra-colonic cancers of LS Ⅱ type.Among the female members of LS family with the MMR gene mutation,EC has an overall lifetime risk more than 35％.LS-associated EC is more likely present as the clinical pathological characteristics of early age of onset,endometrioid adenocarcinoma,lower grade,lower uterine segment involvement,and better prognosis.LS patients with family history and early age of onset should be performed with a combined screening and genetic testing,while high-risk patients should be taken clinical monitoring methods as endometrial biopsy.Oral contraceptives mav be reasonable chemopreventive agents in the patients with LS.Although prophylactic hysterectomy with bilateral salpingo-oophorectomy is an effective strategy to prevent EC in women with LS,preoperative counseling should address the trade-offs between the reduction in the risk of cancer,and the risks and side effects of surgery.The patients need hormone replacement therapy after surgery.