Application of cerebral glucose metabolism in Parkinson's disease patients with cognitive impairment
10.3760/cma.j.issn.1674-6554.2015.08.008
- VernacularTitle:伴认知功能障碍帕金森病的脑葡萄糖代谢研究
- Author:
Meichen LIU
;
Jinghui XIE
;
Hongbo FENG
;
Lanlan PU
;
Zhanhua LIANG
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Cognitive impairment;
Positron emission tomography;
18F-FDG;
SPM
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2015;24(8):702-705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of the cerebral glucose metabolism in Parkinson's disease(PD) with cognitive impairment.Methods Fifty patients with PD and twenty normal controls were enrolled in this study.Based on MMSE score,the PD patients were divided into PD-NC(n=25) and the PDD(n=25) group.Twenty age-and sex-matched physical health examinationer were colleted as control group.Using the SPM to analyze the characteristics of the metabolism in different cognitive level io PD patients.Results (1) Compared with control group,P D-NC group showed significant hypermetabolism in occipital (-24,-92,10),parietal (-48,12,-16) and temporal lobe(52,8,-32).(2)Compared with control group,the glucose metabolism of PDD group decreased in most cerebral cortex and subcortex.(3)Compared with PD-NC group,the metabolism of parietal lobe (-42,-48,40),occipital lobe (-22,-96,-6) and tetnporal lobe (-42,-58,16) reduced in PDD group.Conclusion Cortical brain metabolism decreases in PD-NC group.The degree and scope of glucose metabolism of PDD group will increase with the progress of cognitive dysfunction.These features could help with the diagnosis and differential diagnosis of cognitive dysfunction in Parkinson's disease.
