Dipeptidyl peptidase-Ⅳ : potential implications beyond blood glucose control
10.3760/cma.j.issn.1674-635X.2015.04.011
- VernacularTitle:二肽基肽酶-Ⅳ—血糖控制之外的作用
- Author:
Juan LI
;
Weigang ZHAO
- Publication Type:Journal Article
- Keywords:
Dipeptidyl peptidase-Ⅳ;
Inflammation;
Cardiovascular;
Tumor
- From:
Chinese Journal of Clinical Nutrition
2015;23(4):244-249
- CountryChina
- Language:Chinese
-
Abstract:
Dipeptidyl peptidase-Ⅳ (DPP-Ⅳ/CD26,EC 3.4.14.5),a transmembrane serine polypeptidase,is widely distributed and has diverse effects.As a dipeptidase,DPP-Ⅳ/CD26 could not only regulate the activity of many peptide hormones,neuropeptides,cytokines and growth factors via its peptidase function,but also mediate cell-matrix and cell-cell contact through interactions with other molecules or proteins as a surface antigen.DPP-Ⅳ/CD26 plays a regulatory role in immune activation,inflammation and tumorigenesis.This review covers the structure,distribution,physiological functions and changes in pathological state of Dpp-Ⅳ/CD26.
