The design and application of the machine for making animal model for pressure ulcer
10.3760/cma.j.issn.1672-7088.2015.24.006
- VernacularTitle:动物压疮实验专用模型机的设计与应用
- Author:
Deyu JIANG
;
Zhixia JIANG
;
Aiting ZHOU
;
Rujun HU
;
Xilan ZHENG
- Publication Type:Journal Article
- Keywords:
Models,animal;
Pressure ulcer;
Animal experimentation
- From:
Chinese Journal of Practical Nursing
2015;31(24):1814-1816
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a kind of new machine for making animal model for pressure ulcer,and inspect its effect through experiments,in order to lay the foundation for the research of pressure ulcer experiments on animals.Methods This study developed the machine after reviewing the domestic and foreign literature,making full use of the existing experimental platform of our university.Then 55 Sprague Dawley(SD) rats were selected,after anesthesia and the skin preparation,the researchers imposed certain pressure with 70 mmHg/cm2 (1 mmHg=0.133 kPa) on the skin and muscle tissue on the inner left thigh of SD rats by using self-designed machine,pressing for 2 h,then reperfusion for 30 min,3 times a day,a total of 7 days.Results The authors developed a kind of new machine for making animal model for pressure ulcer,and successfully prepared Ⅲ phase pressure ulcers model in SD rats with success rate of 98.2％(54/55).Conclusion This machine can prepare Ⅲ phase pressure ulcers model on animals,it's easy to use and efficient,it can be used for researches in the field of prevention and cure of pressure ulcers.
