Clinical study of tissue-type plasminogen activator therapy for children's plastic bronchitis

VernacularTitle:组织型纤溶酶原激活剂治疗儿童塑型性支气管炎的疗效
Author: Wei GUO ; Yongsheng XU ; Liya WAN ; Xiaoying CHEN ; Jing NING ; Ming LU ; Fujun LIU
Publication Type:Journal Article
Keywords: Cast bronchitis; Plastic bronchitis; Bronchoscopy; Tissue-type plasminogen activator; Child
From: Chinese Journal of Applied Clinical Pediatrics 2015;30(16):1233-1235
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical efficacy of tissue-type plasminogen activator (tPA) treatment of children with plastic bronchitis.Methods The study retrospectively reviewed the clinical data of the children with plastic bronchitis who were admitted to Tianjin Children's Hospital from September 2013 to January 2015 and were treated with tissue-type plasminogen activator.This study analyzed the effect and safety of tPA treatment,including clinical and radiological changes and follow-ups.Results A lot of plastic secretions were safely removed from the bronchial tubes in all children and clinical manifestations including breathing,body temperature,transcutaneous oxygen saturation and image changes were significantly improved.Conclusions Bronchoscopy is an effective way to treat plastic bronchitis,but with the use of tPA a better clinical efficacy could be achieved.The method is safe and effective and should be applied early in the patients in order to prevent the occurrence of severe airway obstruction complications.