The Risk Factors for Persistence of Asthma Symptoms from Late Childhood to Early Adult Life: The Effects of Pulmonary Function and Bronchial Hyperresponsiveness.
- Author:
Jong Jin PARK
1
;
Jae Jin KIM
;
Im Ju KANG
Author Information
1. Department of Pediatrics, Fatima Hospital, Daegu, Korea. imjukang@hanmail.net
- Publication Type:Original Article
- Keywords:
Pulmonary function;
Bronchial hyperreactivity;
Asthma
- MeSH:
Adult;
Asthma;
Body Mass Index;
Bronchial Hyperreactivity;
Child;
Humans;
Immunoglobulin E;
Methacholine Chloride;
Risk Factors;
Skin Tests
- From:Pediatric Allergy and Respiratory Disease
2008;18(2):138-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We performed this study to evaluate the effect of pulmonary function and bronchial hyperresponsiveness (BHR) on the persistence of asthma symptoms from late childhood to early adult life. METHODS: One-hundred thirty-one children with asthma treated at our hospital during the past 10 years were divided into 2 groups according to the persistence of symptoms in early adult life: the persistent and remission groups. Information about symptoms, body mass index, serum ECP, serum IgE and skin test reactivity in late childhood were obtained and prebronchodilator FEV1, FEV1/FVC (expressed as % of predicted) and BHR to methacholine were measured in late childhood and early adult life, and compared the 2 groups. Results: The persistent group was accounted for 45.8% of the subjects and FEV1, FEV1/ FVC and BHR to methacholine in late childhood were associated with the persistence of symptoms. We found a positive correlation between FEV1 in late childhood and early adult.(r=0.250, P=0.013) Also we found a positive correlation between FEV1/FVC in late childhood and early adult.(r=0.285, P=0.018) BHR and FEV1% of 60% to 79% of late childhood were associated with BHR in early adult.(Odds ratio; 95% confidence interval=3.8; 1.7-8.7, 4.6; 1.0-20.2) Conclusion: Low pulmonary function and increased BHR in childhood asthma were associated with persistence of symptom, degree of pulmonary function and BHR in early adult life.
