Progress of the relationship between the etiology of childhood malignancy and placental disease

VernacularTitle:儿童恶性肿瘤病因学及其与胎盘病变关系的研究进展
Author: Sihui LI ; Xiaoxia PENG ; Xiaoli MA
Publication Type:Journal Article
Keywords: Child; Malignancy; Placental disease; Etiology
From: Chinese Journal of Applied Clinical Pediatrics 2015;30(15):1193-1195
CountryChina
Language:Chinese
Abstract: Childhood cancers are malignancies occured during childhood,which consist of blood-lymphatic system disorders and solid tumor,usually under the age of 15 years old.Among cancers of childhood,solid tumors account for the mainly proportion and most neoplasms are embryonic origin,which are distinctly different from the adult solid tumors.The pathogenesis of children with an oncologic disease,except from the 2 major elements heredity and environment,some experts consider that there are intense correlations between various carcinogenic environment exposure during pregnancy even progestation and childhood cancers.The placenta is a combination of embryo and the maternal tissues,while is a material exchanged organ between 2 parts.One part has a same origin with fetus biological and genetics,and the other provides comprehensive guarantee for fetus normal development in utero.The research of the placental disease of childhood cancers may have a breakthrough in the study of the etiology of pediatric oncology.