The expression and role of monocarboxylate transporter 1 in tumor
10.3760/cma.j.issn.1673-422X.2015.11.010
- VernacularTitle:一元羧酸转运子1在肿瘤中的表达及作用
- Author:
Shanshan TAI
;
Juan WANG
;
Bin CHENG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Metabolism;
Monocarboxylate transporter 1
- From:
Journal of International Oncology
2015;42(11):835-837
- CountryChina
- Language:Chinese
-
Abstract:
The monocarboxylate transporters (MCTs) family, especially MCT1, plays an important role in tumor metabolism.MCT1 mediates a variety of monocarboxylic acids across the plasma membrane, and determines to take in or export lactic acid according to the metaboliuc state, thus maintaining the special tumor cells metabolism model.Considering the emerging evidence for the role of MCT1 in the tumor genesis, metabolism, invasion and metastasis, MCT1 is expected to be a new target for cancer therapy.
