Progress in the relation between cleavage and polyadenylation specific factor and tumor
10.3760/cma.j.issn.1673-4203.2015.08.023
- VernacularTitle:切割与多聚腺苷酸化特异因子与肿瘤相关研究进展
- Author:
Jing CHEN
;
Zhengxiang ZHONG
- Publication Type:Journal Article
- Keywords:
mRNA cleavage and polyadenylation factors;
Neoplasms;
RNA precursors;
Poly(A)-binding proteins
- From:
International Journal of Surgery
2015;42(8):573-576
- CountryChina
- Language:Chinese
-
Abstract:
For human solid tumors,the preferred treatment is surgery.However most patients with clinical diagnosis of tumor is already in advanced,and lost the chance of operation.Cleavage and polyadenylation specific factor is involved in mRNA 3' end cleavage and polyadenine (A) tail,and plays an important role in mRNA maturation and intracellular singal transduction.Under certain conditions,cleavage and polyademletion specific factor can lead to abnormal activation of cancer genes,and then cause tumors.Progress in the relation between cleavage and polyademletion specific factor and tumor was reviewed in the paper.
