MicroRNA-155 in sepsis associated liver injury
10.3760/cma.j.issn.1673-4408.2015.05.016
- VernacularTitle:微小RNA-155与脓毒症肝损伤
- Author:
Xin LYU
- Publication Type:Journal Article
- Keywords:
MicroRNA-155;
Sepsis;
Liver injury
- From:
International Journal of Pediatrics
2015;42(5):541-544
- CountryChina
- Language:Chinese
-
Abstract:
The liver is a crucial organ involved in immune and metabolic processes.In multiple organ dysfunction syndrome secondary to sepsis, liver is one of the target organs.Sepsis-associated liver injury worsens the prognosis and mortality.MicroRNAs are single-stranded,non-coding RNAs.MicroRNAs modulate gene expression post-transcriptionally by binding themselves to complementary sites of target genes and degradation proteins.MicroRNAs affect sepsis pathogenesis at multiple levels through regulating signaling pathways and inflammation factors in immune reaction, as well as functions of immune cells.Among microRNAs involved in sepsis pathogenesis,microRNA-155 is critical in sepsis associated liver injury and it is sketchily described in this review.
