Update on the epigenetics and asthma
10.3760/cma.j.issn.1673-4408.2015.05.010
- VernacularTitle:表观遗传学与哮喘研究进展
- Author:
Nan YANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Epigenetics;
DNA methylation;
Histone modification;
miRNA
- From:
International Journal of Pediatrics
2015;42(5):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic airway inflammatory disease,which is caused by both genetic and environmental factors.For one thing, asthma is associated with genetic factors;for another thing, many exogenous triggering factors,such as diatery intake, smoke exposure and air pollution can impact on the development of asthma.Recently,many studies have showed that epigenetic changes which are influenced by the both factors play an important role in the pathophysiology of asthma.This article reviews the update advances about the epigenetic regulation and epigenetic therapy in asthma.
