Expression of miRNA-31 in serum of children with airway allergic disease
10.3760/cma.j.issn.1673-4408.2015.05.028
- VernacularTitle:微小RNA-31在气道变应性疾病患儿血清中的表达及意义
- Author:
Chaofeng XING
;
Ling LI
- Publication Type:Journal Article
- Keywords:
Asthma;
Allergic rhinitis;
Genes;
regulator;
miRNA-31
- From:
International Journal of Pediatrics
2015;42(5):587-589
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine miRNA-31 expression in serum of children with airway allergic disease (asthma and allergic rhinitis) and determine the correlation with CD44.Methods The expression of miR-NA-31 and CD44 in serum of 26 children with acute asthma and allergic rhinitis and non-acute phase and 36 normal control children were determined by real-time reverse transcriptase polymerase chain reaction.Results The miRNA-31 was significantly overexpressed in serum of children with acute asthma and allergic rhinitis compared with non-acute phase and normal control children and significantly correlated with CD44.Conclusion The correlation between miRNA-31 and CD44, the aberrant expression of miRNA-31 may account for the occurrence and development of airway allergic diseases.
