Neutrophil gelatinase-associated lipocalin and acute kidney injury in children
10.3760/cma.j.issn.1673-4408.2015.05.004
- VernacularTitle:中性粒细胞明胶酶相关载脂蛋白与儿童急性肾损伤的研究进展
- Author:
Ning LIU
- Publication Type:Journal Article
- Keywords:
Neutrophil gelatinase-associated lipocalin;
Acute kidney injury;
Children
- From:
International Journal of Pediatrics
2015;42(5):495-498
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury (AKI) is the most common and serious complication in the intensive care unit.The mortality of AKI is still as high as 60％ in critically ill children because of lack sensitive and special early predictive biomarker.Neutrophil gelatinase-associated lipocalin is one of the most promising early diagnose and predict biomarkers for AKI,produced and secreted by kidney tubule cells at low levels,but increasing dramatically in the urine and serum after ischemic, sepsis, or nephrotoxic injury of the kidneys.This review is to summarize the role of neutrophil gelatinase-associated lipocalin as an early biomarker of AKI with different clinical settings in children.
