Role of 1,25(OH)2 vitamin D3 and vitamin D receptor in chronic kidney kiseases
10.3760/cma.j.issn.1673-4408.2015.05.001
- VernacularTitle:1,25(OH)2维生素D3及维生素D受体在慢性肾脏病中的作用
- Author:
Guohua HE
- Publication Type:Journal Article
- Keywords:
Vitamin D;
Vitamin D receptor;
Chronic kidney disease
- From:
International Journal of Pediatrics
2015;42(5):483-487
- CountryChina
- Language:Chinese
-
Abstract:
1,25 (OH)2 D vitamin3 is the activated form of vitamin D in human body.Mediated by specific vitamin D receptor, 1,25(OH) 2 vitamin D3 plays an important role in many physiological and pathological process.In recent years, researches have shown that 1,25 (OH) 2 vitamin D3 can protect podocytes, inhibit the proliferation of mesenteric cells, regulate the apoptosis of mesenteric cells, anti-inflammation, and have negative effect in rennin-angiotensin system, so as to protect the renal function.This paper reviews the progress of the effect of 1,25(OH)2 vitamin D3 and vitamin D receptor in chronic renal disease.
