Advances in competing endogenous RNA modulation of cancer progression
10.3760/cma.j.issn.1006-9801.2015.08.020
- VernacularTitle:竞争性内源RNA调控肿瘤进程的研究进展
- Author:
Pingping XU
;
Mingjie JIANG
;
Xueying CHEN
;
Di FU
- Publication Type:Journal Article
- Keywords:
Competing endogenous RNA;
microRNA;
Cancer progression
- From:
Cancer Research and Clinic
2015;27(8):568-571
- CountryChina
- Language:Chinese
-
Abstract:
Protein-coding transcriptome,pseudogenes,long non-coding RNAs and circular RNAs can act as competing endogenous RNA (ceRNA).ceRNA can crosstalk with each other through microRNA recognition elements (MRE),thus regulating the post-transcriptional gene expression.More and more evidences showed that ceRNA could form an extensive network of post-transcription regulation,keep the cell homeostasis and involve in the disease development and progression like tumorigenesis and cancer progression.Depending on up-regulation or down-regulation of different kinds of microRNA in different cells,ceRNA acts as either an oncogene or a tumor suppressor.ceRNA may have a great potential in cancer diagnosis and treatment.
