Study on pure red cell aplastic lymphocyte subsets characteristics and the effect of cyclosporin A
10.3760/cma.j.issn.1006-9801.2015.08.006
- VernacularTitle:获得性纯红细胞再生障碍患者淋巴细胞亚群特点及环孢素对其影响的研究
- Author:
Zengsheng WANG
;
Qin HUANG
;
Hong LIU
;
Ling FU
;
Xiaomin WANG
- Publication Type:Journal Article
- Keywords:
Acquired pure red cell aplastic;
T lymphocytes;
Cyclosporine
- From:
Cancer Research and Clinic
2015;27(8):526-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect and analyse acquired pure red cell aplasia (PRCA) T lymphocyte subsets distribution and to assess its condition and cyclosporine immune function of T lymphocytes subsets.Methods Flow cytometry was applicated to detect peripheral blood T lymphocyte subsets of acquired PRCA patients before and after 3 months of treatment with cyclosporine-based immunosuppressive regimen and normal controls.Results Among 22 patients,17 cases of blood returning normal (three cases of bone marrow returning normal),the total effective rate was 95.5 ％ (3 cases of cure,14 cases of remission,4 cases of improvement,1 case of ineffectiveness).Th (CD3+ CD4+) cells and Th/Ts ratios in acquired PRCA patient group were lower than those in the normal control group,while Ts (CD3+ CD8+) cells was higher than that in the normal control group,the differences were statistically significant (P ＜ 0.05).After 3 months of treatment,Th cells and Th/Ts ratio were higher than those before,and Ts cells were decreased compared with the previous (P ＜ 0.05).Conclusion Disorders of T lymphocyte subsets in acquired PRCA patients lead to immune dysfunction,however,cyclosporine can improve T lymphocyte subsets in patients with imbalance,which is an effective way to treat the disease with significant curative effect and mild adverse reactions.
