Value of plasma D-dimer, high-density lipoprotein, carcino embryonic antigen and carbohydrate antigen 724 on diagnosis of gastric cancer
10.3760/cma.j.issn.1006-9801.2015.08.009
- VernacularTitle:D-二聚体、高密度脂蛋白、癌胚抗原和糖类抗原724联合检测在胃癌诊断中的价值
- Author:
Xin WANG
;
Junli CAO
;
Liming GAO
;
Shaohui CHENG
;
Lixin DONG
;
Zhenhong WANG
;
Xiaojing WANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
D-dimer;
High-density lipoprotein;
Carcino embryonic antigen;
Carbohydrate antigen 724
- From:
Cancer Research and Clinic
2015;27(8):535-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of the level of plasma D-dimer,high-density lipoprotein (HDL),carcino embryonic antigen (CEA) and carbohydrate antigen 724 (CA724) in gastric cancer.Methods The plasma and clinicopathological data of 103 gastric cancer patients and 111 normal controls were collected.The levels of D-dimer,HDL,CEA and CA724 were detected.SPSS 13.0 statistical software was applied to analysis the sensitivity and specificity of each examination method and to find out the appropriate combination.Results The levels of D-dimer,CEA and CA724 in patients with gastric carcinoma were 0.87 (2.69) μg/ml,2.66 (4.38) ng/ml,5.10 (7.79) U/ml,respectively,they were distinctly higher than those in normal controls [0.22 (0.21) μg/ml,1.28 (1.60) ng/ml,1.81 (1.60) U/ml,all P =0.000].HDL level was significantly lower in patients than that in normal controls [0.86 (0.35) mmol/L vs 1.29 (0.44) mmol/L,P=0.000].The area ofROC curve of D-dimer,HDL,CEA,CA724 were 0.799,0.859,0.739,0.743,respectively.The cut-off of D-dimer was 0.46 μ.g/ml,the sensitivity was 68.0 ％,the specificity was 86.5 ％.The cut-off of HDL was 0.995 mmol/L,the sensitivity was 73.8 ％,the specificity was 84.7 ％.The cut-off of CEA was 3.585 ng/ml,the sensitivity was 44.7 ％,the specificity was 92.0 ％.The cut-off of CA724 was 3.765 U/ml,the sensitivity was 57.3 ％,the specificity was 89.2 ％.The sensitivity of D-dimer+HDL+CA724 was 83.5 ％,the specificity was 89.2 ％.The sensitivity and specificity of D-dimer+HDL+CEA+CA724 were 84.5 ％ and 89.2 ％,respectively.Conclusions The D-dimer+HDL+CEA+CA724 may provide the evidence for diagnosis of gastric cancer.Combined detection has higher sensitivity and specificity.
