Effect of 89SrCl2 for bone metastasis in Uygur and Han patients with prostate cancer

VernacularTitle:维吾尔族和汉族前列腺癌骨转移患者氯化锶疗效的研究
Author: Ximei FENG ; Shuli GUO ; Yongfang TIAN ; Cheng CHEN ; Hongli WANG
Publication Type:Journal Article
Keywords: Prostatic neoplasms; Strontium; Radionuclide therapy; Bone metastasis
From: Cancer Research and Clinic 2015;27(8):532-534
CountryChina
Language:Chinese
Abstract: Objective To analyze contrastly the effect of 89SrCl2 for bone metastasis in Uygur and Han patients with prostate cancer.Methods The curative effects in 75 Uygur and 82 Han patients with prostate cancer bone metastasis were investigated after intravenous injection with 89SrCl2,including palliation of pain.SPECT was used to detect the change of metastasis,level of prostate-specific antigen (PSA) and interleukin-6 (IL-6) were detected by electrochemiluminescence immunoassay.Results After treated with 89SrCl2,the palliation rate,the bone metastases and the level of IL-6 were higher in Uygur patients [82.67 ％ (62/75),75 ％ (56/75),(4.24±1.74) pg/ml] than those in Han patients [60.98 ％ (50/82),52.44 ％ (43/82),(2.81±2.38) pg/ml],and there were statistically significant (P ＜ 0.05).Conclusion 89SrCl2 is more effective for the Uygur patients with prostate cancer bone metastasis than the Han patients,clinical workers should pay more attention to this.