Association of HLA-DQA1 alleles with systemic lupus erythematosus in populations of Uygur nationality in Xinjiang Uygur Autonomous Region
10.3760/cma.j.issn.0412-4030.2015.10.017
- VernacularTitle:新疆维吾尔族系统性红斑狼疮与HLA-DQA1等位基因相关性研究
- Author:
Wenzheng LI
;
Yuanyuan QU
;
Tingting LI
;
Xiaojing KANG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
HLA antigens;
Gene frequency;
Uygur nationality;
Environment
- From:
Chinese Journal of Dermatology
2015;48(10):731-733
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the association between HLA-DQA 1 alleles and systemic lupus erythematosus (SLE) in populations of Uygur nationality in Xinjiang Uygur Autonomous Region.Methods Polvmerase chain reactionsequence-specific primers (PCR-SSP) were used to analyze the HLA-DQA1 gene in 56 patients with SLE and 54 unrelated healthy controls of Uygur nationalitv in Xinjiang Uygur Autonomous Region.Results Compared with the heahhv controls, the SLE patients showed signifieantly increased frequency of HLA-DQA1*0302 (x2 =10.032, P =0.004), but decreased frequency ofHLA-DQA1*0101 (x2 =5.676, P=0.017).Conclusion HLA-DQA1*0302 may be a susceptibility gene, while HLA-DQA1*0101 may be a protective factor for SLE in populations of Uygur nationality in Xinjiang Uygur Autonomous Region.
