Reliability of mannitol for fluid responsiveness test in patients undergoing intracranial surgery

VernacularTitle:甘露醇用于颅脑外科手术患者液体反应性试验的可靠性
Author: Xinxin SHAO ; Nan JIANG ; Lu YANG ; Xianjun HUANG ; Lijun NIU ; Liangcan XIAO
Publication Type:Journal Article
Keywords: Mannitol; Diagnostic tests,routine; Fluid therapy; Neurosurgical procedures
From: Chinese Journal of Anesthesiology 2015;35(4):457-459
CountryChina
Language:Chinese
Abstract: Objective To evaluate the reliability of mannitol for fluid responsiveness test in the patients undergoing intracranial surgery.Methods Sixty-two ASA physical status Ⅰ or Ⅱ patients,aged 18-64 yr,with body mass index of 18-25 kg/m2,scheduled for elective intracranial surgery,were enrolled in the study.The patients were mechanically ventilated after induction of anesthesia.The radial artery and central vein were cannulated,and FloTracTM/VigileoTM system was connected for stroke volume variation monitoring.Before infusion of mannitol,effective circulating blood volume was confirmed according to stroke volume variation.20％ mannitol 250 ml was infused over 20 min starting from onset of craniotomy.The fluid responsiveness test was recorded at the end of mannitol infusion.Results The sensitivity of fluid responsiveness test was 43％,and the specificity of fluid responsiveness test was 44％.Conclusion Mannitol can not be used for fluid responsiveness test in the patients undergoing intracranial surgery.