Temporal alteration of stone composition and onset age in the upper urinary tract: a cross-sectional study of 1 878 cases
10.3760/cma.j.issn.1000-6702.2015.08.015
- VernacularTitle:1878例上尿路结石成分和发病年龄随时间变迁的横断面研究
- Author:
Wei WANG
;
Fengning MA
;
Ruixian PENG
;
Zhiyuan LIN
;
Guowei SHI
;
Qiang DING
;
Jiayang HE
- Publication Type:Journal Article
- Keywords:
Urinary calculi;
Upper urinary tract;
Stone analysis;
Uric acid;
Cross-sectional studies
- From:
Chinese Journal of Urology
2015;36(8):620-623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate if distribution of stone composition and onset age in the upper urinary tract changed during the past 12 years in China.Methods There were 1 878 urolithiasis patients of the upper urinary tract in our hospital from 2003 to 2014 enrolled in present cross-sectional study.There were 1 300 male and 578 female patients with a median onset age of 46 (6-95) years.Stone composition was measured by infrared spectrophotometry.All the patients were divided into 3 groups according to the onset year:Year 2003-2006,Year 2007-2010 and Year 2011-2014.The distributions of stone types were compared among the 3 groups.Age and gender were included as potential confounders.Chi square test,P trend test,Kruskal-Wallis test and logistic regression were employed in the statistical analysis.Results Calcium oxalate was the most common type with a dominant proportion of 78.1％ (1 466/1 878),while uric acid had a small proportion of 4.8％ (91/1 878).The proportions of uric acid in the 3 groups were 2.7％ (12/441),5.1％ (39/758) and 5.9％ (40/679),showing an increasing trend (P ＜0.05).Multivariate analysis showed that year group was independently correlated with the proportion of uric acid,with an OR of 1.385 (95％ CI,1.027-1.867).From 2003 to 2014,the proportion of uric acid calculus increased by 0.42％ (95％ CI,0.25％-0.59％) annually.The median ages of disease onset were 43,46 and 49 years respectively in those three groups,also showing an increasing trend with time (P ＜0.01).Conclusion From 2003 to 2014,the proportion of uric acid and onset age in patients of upper urinary tract calculi were increased in the present cohort.
