Relationship between JAK2 V617F gene mutation and vascular embolism diseases
10.3760/cma.j.issn.1009-9921.2015.07.013
- VernacularTitle:JAK2 V617F基因突变与血管栓塞性疾病的相关性研究
- Author:
Wei ZHANG
;
Yan LIU
;
Suigui WAN
;
Hong ZHAO
;
Wanling SUN
;
Ding TIAN
- Publication Type:Journal Article
- Keywords:
Myeloproliferative neoplasms;
JAK2 V617F gene mutation;
Embolism
- From:
Journal of Leukemia & Lymphoma
2015;24(7):431-432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between JAK2 V617F mutation and vascular embolism diseases,in order to provide important basis for clinical diagnosis and treatment and prevention of embolism.Methods Patients who were hemoglobin ＞ 160 g/L,platelets ＞ 300×109/L treated in department of neurology,heart and vascular surgery in Xuanwu Hospital of Capital Medical University were collected.Vessel embolism and JAK2 V617F mutation situation and correlation were retrospectively analyzed.Results Among the total 56 cases,JAK2 V617F gene mutation positive rate was 37.50 ％ (21/56),the incidence of embolism was 40.07 ％ (23/56),there was correlation between JAK2 V617F mutation and embolism (P =0.014).Conclusion JAK2 V617F mutation is helpful to early diagnosis and treatment of myeloproliferative neoplasm,reduce thrombosis complication,improve the quality of life.
