Abnormal clones and clonal evolution of bcr-abl-negative myeloproliferative neoplasms
10.3760/cma.j.issn.1009-9921.2015.07.009
- VernacularTitle:bcr-abl阴性骨髓增殖性肿瘤的异常克隆及演化
- Author:
Na XU
;
Li DING
;
Xiaoli LIU
- Publication Type:Journal Article
- Keywords:
Myeloproliferative neoplasms;
Abnormal clones;
Clonal evolution
- From:
Journal of Leukemia & Lymphoma
2015;24(7):415-419
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,studies committed to the myeloproliferative neoplasms (MPN) pathogenesis suggest that potential somatic genetic alterations,and epigenetic events might contribute to MPN development,influence the MPN disease phenotype,progression,and promote transformation.The most relevant mutations identified so far can be broadly classified into two main groups.Mutations associated with dysregulated JAK-STATsignal transduction pathway,including mutations in JAK2,CALR,MPL,CBL,LNK,SOCS.Mutations in several epigenetic modifiers,including mutations in TET2,ASXL1,IDH1/2,DNMT3A,EZH2 and so on.In this paper,the abnormal clones and clonal evolution of MPN were reviewed.
