Clinical and pathological characteristics and the expression of interleukin-6, interleukin-17 and tumor necrosis factor-α in elderly patients with primary nephrotic syndrome
10.3760/cma.j.issn.0254-9026.2015.11.015
- VernacularTitle:老年原发性肾病综合征患者临床病理特征及血清中炎性因子的表达
- Author:
Jingrong HUANG
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
Interleukin-6;
Interleukin-17;
Tumor necrosis factor-alpha
- From:
Chinese Journal of Geriatrics
2015;34(11):1207-1209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical and pathological characteristics and the expression of interleukin (IL)-6, IL-17 and tumor necrosis factor (TNF)-α in elderly patients with primary nephrotic syndrome.Methods A total of 75 elderly cases with primary nephrotic syndrome were chosen as the observation group, and 40 healthy elderly persons served as the control group.Fasting serum IL-6, IL-17 and TNF-α levels were measured by enzyme-linked immunosorbent assay (ELISA) for both groups.Results 67 of the 75 patients received pathological diagnoses, of whom 46 had membranous glomerulonephritis, 5 had focal segmental glomerulosclerosis, 5 had mesangiocapillary glomerulonephritis, 3 had mesangial proliferative glomerulonephritis, 3 had IgA nephropathy, and the rest included one case for each of the following disorders: glomerular minor lesion, sclerosing glomerulonephritis, diffuse proliferative glomerulonephritis, segmental proliferative glomerulonephritis, and minor glomerular lesions.The expression of IL-6, IL-17 and TNF-α had statistically significant differences between the two groups.There were no statistically significant differences in the expression of IL-6 and IL-17 between patients with different pathological characteristics, and the expression of TNF-α was higher in membranous glomerulonephritis patients than in patients with other pathological characteristics.Conclusions Membranous glomerulonephritis is the main pathological type in elderly patients with primary nephrotic syndrome.Serum IL-6, IL-17 and most notably TNF-α levels are elevated in patients with membranous glomerulonephritis.
