Association of C-MET Protein Expression with Survival in Patients with Stage Ⅲ Gastric Cancer:A Retrospective Analysis
10.3969/j.issn.1008-7125.2015.11.006
- VernacularTitle:C-MET蛋白表达与Ⅲ期胃癌患者生存关系的回顾性分析
- Author:
Lijun WANG
;
Ting LIU
;
Lixia HU
;
Yongchao ZHANG
;
Huili GUO
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms;
Proto-Oncogene Proteinsc-met;
Prognosis
- From:
Chinese Journal of Gastroenterology
2015;(11):663-666
- CountryChina
- Language:Chinese
-
Abstract:
Background:C-MET is expressed in a variety of tumor,and its expression may help to predict the prognosis of patients with gastric cancer. Aims:To explore the association of C-MET protein expression with survival in patients with stage Ⅲ gastric cancer. Methods:A total of 178 consecutive initially treated patients with stage Ⅲ gastric cancer from April 2010 to April 2014 at Beijing Pinggu Hospital were enrolled in this study. The expression of C-MET protein was determined by immunohistochemistry. Kaplan-Meier method was used to analyze the survival in patients with high C-MET protein expression and low C-MET protein expression,COX proportional hazards model was used to analyze the influence of various factors on prognosis. Results:C-MET protein was low expressed in 139 patients(78. 1%),and high expressed in 39 patients(21. 9%). Median survival(25. 1 months vs. 45. 0 months),1-year survival rate(69. 2% vs. 91. 4%),2-year survival rate(41. 0% vs. 84. 0%)were significantly decreased in high C-MET protein expression group than in low C-MET protein expression group(P all <0. 05). C-MET protein expression,N staging,and age were the influencing factor for prognosis of gastric cancer(P all <0. 05),however,gender and tumor differentiation were not related with prognosis(P>0. 05). Conclusions:C-MET protein expression rate is 21. 9% in patients with stageⅢgastric cancer,C-MET expression is significantly associated with survival;1-year survival rate is lower in patients with high C-MET protein expression.
