Abnormal Autophagy in Pathogenesis of Inflammatory Bowel Disease
10.3969/j.issn.1008-7125.2015.11.011
- VernacularTitle:自噬异常在炎症性肠病发病机制中的作用
- Author:
Cong ZHANG
;
Yingwei CHEN
- Publication Type:Journal Article
- Keywords:
Autophagy;
Inflammatory Bowel Disease;
Crohn Disease;
Colitis,Ulcerative;
Pathogenesis;
Genome-Wide Association Study
- From:
Chinese Journal of Gastroenterology
2015;(11):683-686
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease( IBD)is a chronic and nonspecific intestinal inflammatory disease caused by multiple factors such as environment,genetic susceptibility and immune disturbance. Autophagy plays an important role in cellular homeostasis and immune. Autophagy abnormalities may be involved in the pathogenesis of IBD. Genome-wide association studies(GWAS)have provided compelling evidence that autophagy related genes,including ATG16L1,IRGM and NOD2,are significantly associated with IBD. This article reviewed the abnormal autophagy in pathogenesis of IBD.
