A comparative study of p1 6 gene methylation status in primary tongue squamous cell carcinoma and cervical lymph node metastasis
- VernacularTitle:舌鳞癌原发灶及其颈部淋巴转移灶中 p16基因甲基化状态的比较研究
- Author:
Xi LIN
;
Xuanping HUANG
;
Yilin WU
;
Huashen XU
- Publication Type:Journal Article
- Keywords:
Tongue squamous cell carcinoma(TSCC);
p1 6 gene;
Methylation;
Reverse methylation treatment
- From:
Journal of Practical Stomatology
2015;(6):868-871
- CountryChina
- Language:Chinese
-
Abstract:
DNA from 32 cases of tongue squamous cell carcinoma(TSCC)specimens and the neck lymph node metastasis specimens were processed by bisulfite treatment.The methylation of the specimens was examined by Q-MSP amplification.The consistency of p1 6 methyla-tion of primary TSCC with that of lymph node metastasis tumor was 90.62%(P <0.05).We assumed that p1 6 gene promoter CpG island methylation rates in primary TSCC and metastatic lymph nodes are consistent,p1 6 gene methylation status can be a methylation predictor be-tween premary and lymph node metstasized TSCC.
